解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::The simian hemorrhagic fever virus (SHFV) genome differs from those of other members of the family Arterivirus in encoding two adjacent sets of four minor structural protein open reading frames (ORFs). A stable, full-length, infectious SHFV-LVR cDNA clone was constructed. Virus produced from this clone had replication...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2014.06.001
更新日期:2014-08-01 00:00:00
abstract::The Hepatitis B virus Precore protein, present in the secretory pathway as the HBeAg precursor, can associate in the cytoplasm with the Core protein to form heterocapsids, likely to favor viral persistence. Core and Precore proteins share their primary sequence except for ten additional aminoacids at the N-terminus of...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2014.06.013
更新日期:2014-08-01 00:00:00
abstract::The response to influenza virus (IAV) infection and severity of disease is highly variable in humans. We hypothesized that one factor contributing to this variability is the presence of specific respiratory tract (RT) microbes. One such microbe is Streptococcus pneumoniae (Sp) that is carried asymptomatically in the R...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2014.06.019
更新日期:2014-08-01 00:00:00
abstract::The existence and genetic make-up of most primate retroviruses was revealed by studies of bushmeat and fecal samples from unhabituated primate communities. For these, detailed data on intra- and within-species contact rates are generally missing, which makes identification of factors influencing transmission a challen...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2014.05.012
更新日期:2014-07-01 00:00:00
abstract::Urine and breast milk represent the main routes of human cytomegalovirus (HCMV) transmission but the contribution of renal and mammary epithelial cells to viral excretion remains unclear. We observed that kidney and mammary epithelial cells were permissive to HCMV infection and expressed immediate early, early and lat...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2014.04.032
更新日期:2014-07-01 00:00:00
abstract::The hepatitis B virus (HBV) is formed by budding. A stretch of 22 amino acids (aa) (matrix domain, MD, R103 - S124) in the large envelope protein L is crucial for virion formation and probably establishes contact to the nucleocapsid. Here, we assess the impact of sequence variations at numerous individual aa positions...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2014.04.030
更新日期:2014-06-01 00:00:00
abstract::Adenovirus-mediated virotherapy is one of the promising therapeutic approaches for glioma treatment. However, its replication efficiency and specificity still failed to meet the requirements for clinical treatment. To improve the anti-tumor activity and specificity of oncolytic adenoviruses (OA), we applied multiple m...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2014.04.007
更新日期:2014-06-01 00:00:00
abstract::We investigated the origin and the effect of insertion D67D-THGERDLGPA within HIV-1 RT from a patient failing antiviral therapy. The insertion developed within the context of pre-existing NRTI and NNRTI mutations (M41L, L210W, T215Y and N348I). Concurrently, the NRTI mutations T69I and V118I and the NNRTI mutations K1...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2014.03.023
更新日期:2014-05-01 00:00:00
abstract::Adenovirus inundates the productively infected cell with linear, double-stranded DNA and an abundance of single-stranded DNA. The cellular response to this stimulus is antagonized by the adenoviral E1B and E4 early genes. A mutant group C adenovirus that fails to express the E1B-55K and E4orf3 genes is unable to suppr...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2014.03.010
更新日期:2014-05-01 00:00:00
abstract::Currently, little is known about the ankyrin/F-box protein B4. Here, we report that B4R-null viruses exhibited reduced plaque size in tissue culture, and decreased ability to spread, as assessed by multiple-step growth analysis. Electron microscopy indicated that B4R-null viruses still formed mature and extracellular ...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2014.03.019
更新日期:2014-05-01 00:00:00
abstract::Astrocytes protect neurons but also evoke a proinflammatory response to injury and viral infections including HIV. We investigated the mechanism of HIV-1 infection in primary astrocytes, which showed minimal but productive viral infection independent of CXCR4. As with ectopic-CD4-expressing astrocytes, lysosomotropic ...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2014.03.002
更新日期:2014-05-01 00:00:00
abstract::The measles virus (MV) vaccine lineage is a promising oncolytic but prior exposure to the measles vaccine or wild-type MV strains limits treatment utility due to the presence of anti-measles antibodies. MV entry can be redirected by displaying a polypeptide ligand on the Hemagglutinin (H) C-terminus. We hypothesized t...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2014.01.027
更新日期:2014-04-01 00:00:00
abstract::The role of binding kinetics in determining neutralizing potency for antiviral antibodies is poorly understood. While it is believed that increased steady-state affinity correlates positively with increased virus-neutralizing activity, the relationship between association or dissociation rate and neutralization potenc...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2014.02.010
更新日期:2014-04-01 00:00:00
abstract::The nucleoprotein (NP) of the influenza A virus encapsidates the viral RNA and participates in the infectious life cycle of the virus. The aims of this study were to find the degree of conservation of NP among all virus subtypes and hosts and to identify conserved binding sites, which may be utilised as potential drug...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2014.01.023
更新日期:2014-04-01 00:00:00
abstract::How the H7N9 avian influenza virus gained the distinct ability to infect humans is unclear. Pigs are an important host in influenza virus ecology because they are susceptible to infection with both avian and human influenza viruses and are often involved in interspecies transmission. Here, we passaged one avian isolat...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2014.01.016
更新日期:2014-03-01 00:00:00
abstract::Tombusviruses replicate on pre-existing organelles such as peroxisomes or mitochondria, the membranes of which become extensively reorganized into multivesicular bodies (MVBs) during the infection process. Cucumber necrosis virus (CNV) has previously been shown to replicate in association with peroxisomes in yeast. We...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2013.12.035
更新日期:2014-03-01 00:00:00
abstract::The recent identification of a novel human coronavirus responsible of a SARS-like illness in the Middle-East a decade after the SARS pandemic, demonstrates that reemergence of a SARS-like coronavirus from an animal reservoir remains a credible threat. Because SARS is contracted by aerosolized contamination of the resp...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2014.01.002
更新日期:2014-03-01 00:00:00
abstract::We characterized three subsets of NK cells in blood, and two subsets in mucosal tissues. SIVmac251 infection increased total and CD16(+) NK cells in the blood. In the rectum, we observed a significant increase in total and NKG2A(+) NK cells during SIV infection. In contrast, the NKp44(+) subset significantly depleted ...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2013.12.003
更新日期:2014-02-01 00:00:00
abstract::Potato spindle tuber viroid (PSTVd) is a small non-protein-coding RNA pathogen that can induce disease symptoms in a variety of plant species. How PSTVd induces disease symptoms is a long standing question. It has been suggested that PSTVd-derived small RNAs (sRNAs) could direct RNA silencing of a targeted host gene(s...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2013.12.019
更新日期:2014-02-01 00:00:00
abstract::Adenoviruses (Ads) infect hosts from all vertebrate species and have been investigated as vaccine vectors. We report here near-atomic structures of two bovine Ad type 3 (BAd3) intermediates obtained by cryo-electron microscopy. A comparison between the two intermediate structures reveals that the differences are local...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2013.12.012
更新日期:2014-02-01 00:00:00
abstract::Phage ΦM12 is an important transducing phage of the nitrogen-fixing rhizobial bacterium Sinorhizobium meliloti. Here we report the genome, phylogenetic analysis, and proteome of ΦM12, the first report of the genome and proteome of a rhizobium-infecting T4-superfamily phage. The structural genes of ΦM12 are most simila...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2013.11.027
更新日期:2014-02-01 00:00:00
abstract::In HIV-1 infection, plasma viral load (VL) has dual implications for pathogenesis and public health. Based on well-known patterns of HIV-1 evolution and immune escape, we hypothesized that VL is an evolving quantitative trait that depends heavily on duration of infection (DOI), demographic features, human leukocyte an...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2013.11.024
更新日期:2014-01-20 00:00:00
abstract::Inflammasome activation is gaining recognition as an important mechanism for protection during viral infection. Here, we investigate whether Rift Valley fever virus, a negative-strand RNA virus, can induce inflammasome responses and IL-1β processing in immune cells. We have determined that RVFV induces NLRP3 inflammas...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2013.11.015
更新日期:2014-01-20 00:00:00
abstract::Vif is essential for HIV-1 replication in T cells and macrophages. Vif recruits a host ubiquitin ligase complex to promote proteasomal degradation of the APOBEC3 restriction factors by poly-ubiquitination. The cellular transcription cofactor CBFβ is required for Vif function by stabilizing the Vif protein and promotin...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2013.11.004
更新日期:2014-01-20 00:00:00
abstract::Ubiquitin C-terminal Hydrolase L1 (UCH-L1) has oncogenic properties and is highly expressed during malignancies. We recently documented that Epstein-Barr virus (EBV) infection induces uch-l1 expression. Here we show that Kaposi's Sarcoma-associated herpesvirus (KSHV) infection induced UCH-L1 expression, via cooperatio...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2013.10.018
更新日期:2014-01-05 00:00:00
abstract::KSHV establishes characteristic latent infections in vitro, while RRV, a related macaque rhadinovirus, establishes characteristic permissive infections with virus replication. We identified cells that are not permissive for RRV replication and recapitulate the latent KSHV infection and reactivation processes. The RRV ...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2013.10.013
更新日期:2014-01-05 00:00:00
abstract::Pandemic H1N1 influenza A (H1N1pdm) elicits stronger pulmonary inflammation than previously circulating seasonal H1N1 influenza A (sH1N1), yet mechanisms of inflammatory activation in respiratory epithelial cells during H1N1pdm infection are unclear. We investigated host responses to H1N1pdm/sH1N1 infection and virus ...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2013.09.022
更新日期:2014-01-05 00:00:00
abstract::Cultured primary peripheral blood mononuclear cells (PBMC) represent a potentially physiologic in vitro model of HIV-1 infection, but assessment of antibody-mediated HIV-1 neutralization using PBMC has been hindered by donor variability and lack of a sustainable individual PBMC source. To advance this model for HIV va...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2013.09.014
更新日期:2013-12-01 00:00:00
abstract::The HPV16 E7 oncoprotein and 17β-estradiol are important factors for the induction of premalignant lesions and cervical cancer. The study of these factors is crucial for a better understanding of cervical tumorigenesis. Here, we assessed the global gene expression profiles induced by the HPV16 E7 oncoprotein and/or 17...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2013.08.036
更新日期:2013-12-01 00:00:00
abstract::In our in vitro model for HPV16-mediated transformation, HPV16-immortalized human keratinocytes (HKc/HPV16) give rise to differentiation resistant, premalignant cells (HKc/DR). HKc/DR, but not HKc/HPV16, are resistant to growth inhibition by transforming growth factor beta (TGF-β), due to a partial loss of TGF-β recep...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2013.08.034
更新日期:2013-12-01 00:00:00
abstract::Nucleos(t)ide analogues that inhibit hepatitis B virus (HBV) DNA replication are typically used as monotherapy for chronically infected patients. Treatment with a nucleos(t)ide analogue eliminates most HBV DNA replication intermediates and produces a gradual decline in levels of covalently closed circular DNA (cccDNA)...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2013.08.014
更新日期:2013-11-01 00:00:00
abstract::The current antiretroviral therapy (ART) can effectively reduce plasma HIV loads to undetectable levels, but cannot eliminate latently infected resting memory CD4 T cells that persist for the lifetime of infected patients. Therefore, designing new therapeutic approaches to eliminate these latently infected cells or th...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2013.08.002
更新日期:2013-11-01 00:00:00
abstract::Inhibition of cellular respiration, oxidation of glutathione and induction of apoptosis have been reported in epithelial cells infected in vitro with influenza A virus (IAV). Here, the same biomarkers were investigated in vivo by assessing the lungs of BALB/c mice infected with IAV. Cellular respiration declined on da...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2013.07.034
更新日期:2013-11-01 00:00:00
abstract::HIV CRF07 B'/C is a strain circulating mainly in northwest region of China. The gp41 region of CRF07 is derived from a clade C virus. In order to compare the difference of CRF07 gp41 with that of typical clade B virus, we solved the crystal structure of the core region of CRF07 gp41. Compared with clade B gp41, CRF07 ...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2013.07.024
更新日期:2013-11-01 00:00:00
abstract::Human papilllomaviruses (HPVs) are common human pathogens that infect cutaneous or mucosal epithelia in which they cause warts, self-contained benign lesions that commonly regress. The HPV life cycle is intricately tied to the differentiation of the host epithelium it infects. Mucosotropic HPVs are the most common sex...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2013.07.016
更新日期:2013-10-01 00:00:00
abstract::The role of oxygen tension level is a well-known phenomenon that has been studied in oncology and radiotherapy since about 60 years. Oxygen tension may inhibit or stimulate propagation of viruses in vitro as well as in vivo. In turn modulating oxygen metabolism may constitute a novel approach to treat viral infections...
journal_title:Virology
pub_type: 杂志文章,评审
doi:10.1016/j.virol.2013.06.018
更新日期:2013-09-01 00:00:00
abstract::The HIV-1 protein Vpr enhances macrophage infection, triggers G2 cell cycle arrest, and targets cells for NK-cell killing. Vpr acts through the CRL4(DCAF1) ubiquitin ligase complex to cause G2 arrest and trigger expression of NK ligands. Corresponding ubiquitination targets have not been identified. UNG2 and SMUG1 are...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2013.06.010
更新日期:2013-09-01 00:00:00
abstract::We compared the levels of the Ski oncoprotein, an inhibitor of transforming growth factor-beta (TGF-β) signaling, in normal human keratinocytes (HKc), HPV16 immortalized HKc (HKc/HPV16), and differentiation resistant HKc/HPV16 (HKc/DR) in the absence and presence of TGF-β. Steady-state Ski protein levels increased in ...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2013.05.039
更新日期:2013-09-01 00:00:00
abstract::Varicella Zoster virus (VZV) productively infects humans causing varicella upon primary infection and herpes zoster upon reactivation from latency in neurons. In vitro studies using cell-associated VZV infection have demonstrated productive VZV-infection, while a few recent studies of human neurons derived from stem c...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2013.05.021
更新日期:2013-09-01 00:00:00
abstract::RNA silencing is a fundamental antiviral response in eukaryotic organisms. We investigated the counterdefense strategy of a fungal virus (mycovirus) against RNA silencing in the white root rot fungus, Rosellinia necatrix. We generated an R. necatrix strain that constitutively induced RNA silencing of the exogenous gre...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2013.07.010
更新日期:2013-09-01 00:00:00